The closest to the pin contest features 30 players from across the sports and entertainment worlds including Justin Timberlake, Peyton Manning, Mark Wahlberg, Bill Murray and Toby Keith. They will develop and apply this powerful new technology toward creating a comprehensive reagent set aimed at the Hepatitis C virus HCV proteome. RAR Telomeres comprise DNA sequences at the ends of chromosomes which shorten by about base pairs per year on average in humans due to oxidation and incomplete DNA replication during the cell cycle. Our approach challenges the current focus on quantitative identification of synaptic RNAs by developing new technologies to address protein synthesis-dependent synaptic plasticity: United States of America. As computed interaction models emerge, these will be studied by biophysical and structural methods using natural, as well as designed RNA recognition element representing RNA ligands together with their respective recombinant proteins. The Baltimore Orioles have announced that Gary Thorne will be returning as their TV play-by-play voice next season and Amber Theoharis will return as the in-game reporter.
The Ranganathan laboratory focuses on understanding the basic principles of structure, function, and evolvability in biological systems, with particular focus on the atomic and cellular scale.
His work has led to new models for the architecture of natural proteins and to new experimental tools for studying the physics and evolution of proteins and cellular systems. After earning his B. Griffin at the Massachusetts Institute of Technology and earned his Ph. In this T-R01 project, Rienstra will develop new and improved multidimensional SSNMR technologies for the study of lipids and spearhead interrelated collaborative efforts to prepare isotopically enriched lipids and to integrate the SSNMR data sets into molecular dynamics simulations.
Together these tools will enable atomic resolution insights into how lipid structures and dynamics determine function. His laboratory uses fishes, amphibians, and reptiles to explore the evolutionary and integrative mechanisms underlying adaptive phenotypic responses with a focus on the regulation of GI performance. He received his B. During his post-doctoral training with Dr. Unmatched in the magnitudes of morphological and physiological responses, the python model is providing valuable insight into the regulatory mechanisms that trigger the rapid enhancement and suppression of cellular form and function.
His research focuses on the development of novel molecular modeling and simulation technologies and employing them to characterize the structural and dynamical bases of function of biomolecular processes. His lab has been at the forefront of computational studies of biological membranes and membrane proteins. Some major areas of research include the mechanism of membrane transport proteins, lipid-dependent binding of peripheral proteins to the surface of the membrane, and application of nanotechnology to biological problems.
The computational tools and methodologies contributed by his lab are essential to developing atomic-scale models for specific lipid- protein interactions that control the function of a large array of membrane-associated proteins. He has recently been selected as a University of Illinois Scholar and received a faculty excellence award.
Her group's research focuses on identifying small molecules capable of increasing pancreatic beta cell number and function, with the ultimate goal of treating diabetes. Wagner received an A. She received her PhD in Neuroscience from Rockefeller University in , completed postdoctoral training in the Department of Neurological Surgery at the University of Washington, and joined the Northwestern faculty as an Assistant professor in Research in her laboratory is broadly aimed at understanding estrogen modulation of synaptic structure and function in the adult brain, from molecular mechanisms to behavioral consequences.
Current work is focused on estrogens synthesized directly within the brain and understanding how brain-derived estrogens influence neural circuit function in both sexes. She received her B. Her laboratory studies genome organization, chromosome behavior, and inheritance and, along these lines, they investigate the phenomenon of somatic homolog pairing, explore the potential of sequence ultraconservation to maintain genome integrity, and develop and apply technologies to image all aspects of the genome.
Glenn Center for the Biology of Aging. Yankner graduated from Princeton University, received his M. Work from his laboratory has also defined the transcriptome of the aging human brain, its evolution, and a role for DNA damage in brain aging.
He has published over peer reviewed papers, received 7 US and over 30 international patents. Principles, Designs and Applications in Biomedical Engineering.
Xiaowei Zhuang is the David B. Her research is focused on the development and application of advanced imaging methods, in particular single-molecule and super-resolution imaging, as well as transcriptome imaging methods, for the studies of biological systems.
She obtained her Ph. Allbritton's research studies, described in over publications, are directed at the development of new technologies by bringing to bear methods from engineering, chemistry, physics and biology to address biomedical problems.
Prior to joining UC Davis, Dr. Badawi worked at St. His current research interests include PET and multimodality imaging instrumentation, image processing, and imaging in clinical trials. Barker has made seminal contributions to the field by establishing the cell-level mechanics of human lung fibrosis tissue and its effect on epithelial-to- mesenchymal transition and myofibroblast differentiation. Future efforts of Dr. Barker will focus on the elucidation of fibroblast heterogeneity that emerges during tissue fibrosis and wound repair, exploration of novel mechanistic insights into fibroblast mecahnotransduction, and the development of technologies that leverage, or hijack, endogenous cell mechanotransduction for therapeutic gain.
Scott received his Ph. Rick Woychik's lab at the Oak Ridge National Laboratory where he cloned and molecularly characterized a classical coat-color gene in the mouse called the agouti locus. As a postdoctoral fellow in Dr. As a PI, he has continued to develop and utilize mouse models of development and disease. Currently, his lab is particularly interested in identifying gut microbiota and microbial metabolites that influence colorectal cancer progression and elucidating their mechansims of action.
Dana Dolinoy is an Associate Professor of Environmental Health Sciences and Nutritional Sciences at the University of Michigan School of Public Health and leads the Environmental Epigenetics and Nutrition Laboratory, which investigates how nutritional and environmental factors interact with epigenetic gene regulation to shape health and disease.
Dolinoy holds a B. Her research focuses on examining the extent and implications of bacterial DNA integrations into animal genomes, including the human somatic genome. She has been at the forefront of research demonstrating that bacterial DNA integrations are extensive in invertebrates, sometimes encompassing multiple bacterial genomes.
Through an NIH New Innovator Award awarded in , her group used bioinformatics to demonstrate that such integrations are present in the human somatic genome where some are positioned in a manner where they could be oncogenic. He received his Eng. Research in his lab focuses on bioinformatics and computational systems biology, with particular emphasis on understanding the architecture and dynamics of gene-regulatory and signaling networks in human disease.
Hetzer received his Ph. He joined the faculty at the Salk as an Assistant Professor in and became Full Professor in His research focuses on fundamental aspects of organismal aging with a special focus on the heart and central nervous system. His laboratory has also made important contributions in the area of cancer research and cell differentiation. With a regenerative medicine focus, Scott conducted two post-doctoral fellowships, the first was to investigate the molecular pathogenesis of liver fibrosis and the second to define mechanisms driving neural stem cell maintenance.
His research program is broadly aimed at understanding single stem cell dynamics in the intestine and leveraging this information to develop physiologically relevant tissue constructs for cell-based therapies. Edward Mocarski started his career at Stanford University in where he served as Chairman of the Department of Microbiology and Immunology and Associate Dean for Research before becoming Professor Emeritus in as he accepted an appointment as Robert W.
He has made key contributions to the identification of replication functions, latent reservoir in myelomonocytic progenitors, immunomodulatory functions, and cellular response to viral infection. Recent studies of CMV-encoded inhibitors of cell death brought to light novel programmed cell death pathways that play out in mammals as alternatives to effectively eliminate pathogens that block apoptosis. He has discovered that mammalian cell death machinery may become dysregulated to cause developmental failure as well as inflammatory disease.
Saeed Tavazoie received his B. The main focus of his research is to understand how cells adapt to changes in their external environment. His lab studies this systems-level phenomenon across a range of timescales, from rapid transcriptional responses, to multi-generational epigenetic reprogramming, to long-term rewiring of signaling and regulatory networks over evolutionary timescales. These studies have furthered our understanding of how environmental fluctuations are interpreted by cells; how global modulation of gene expression contributes to adaptation; how reprogramming of gene expression is encoded in DNA and RNA regulatory sequences; and how regulatory network rewiring underlies diverse phenomena of clinical relevance including antibiotic tolerance and cancer progression.
Zhang is a bioengineer focused on developing tools to better understand brain function and treat neurological and psychiatric disorders. Current research in the Zhang laboratory is centered on the development and application of the next generation of genome engineering tools to dissect the effects of genetic and epigenetic variation on the nervous system.
Redesigning the T cell: The proposed research will pursue improving cell and animal models for human brain disorders, as well as develop novel cell therapy strategies for brain diseases.
Recently, our group succeeded in the directed conversion of human patient skin fibroblasts to neurons, achieved by introducing a 'cocktail' of pro-neural factors.
Such cell reprogramming approaches may allow for the facile generation of replacement cells for some brain disorders.
The ultimate goal is to apply this technology to model Alzheimer disease pathology, with the intention of pursuing disease mechanisms and test potential therapies.
The evolution and ontogeny of lifespan at the species and individual level, the energetics of the organism in its environment, the storage of metabolizable energy as body fat, and socioeconomic disparities within populations all seem intricately related and yet the nature of these interrelations is poorly understood. Indeed questions as fundamental as why people age remain open and subsidiary questions such as why caloric restriction leads to increased lifespan and why lower socioeconomic status is related to obesity in developed countries also remain unanswered.
The research proposes a unified model informed by evolutionary thinking about life strategies which connects these phenomena. In this model, aging or more precisely senescence is not something that passively happens to people as the result of environmental insults or from metabolizing fuel. That is, mortality rate or the rate of aging is seen as partially internally regulable phenomenon much like the control of body temperature in homeotherms in which the regulated rate is responsive to perceptions about the energetic state of the environment.
From this perspective, it is perceptions of the energetic security of the environment that are a key factor in linking these phenomena. We test this hypothesis using model organisms followed by mechanistic work involving internal clock regulation and other potential mechanisms. Development of new and more effective therapies for Type 2 diabetes T2DM and coronary artery disease CAD requires improved understanding of disease mechanisms. Genome sequencing in human populations identifies genes and mutations underlying the inherited contribution to disease susceptibility, but progress is slowed by two central challenges: Our project addresses these challenges by integrating data and methods from human genetics, genome engineering, and stem cell biology, and is made possible by three recent advances: By engineering human stem cells to carry specific mutations, and by differentiating these engineered stem cells into physiologically relevant human metabolic cell types, we will make it possible to study the impact of large numbers of gene variants on human cell biology and function.
By relating the functions of gene mutations and cell biological processes with the phenotypes of human patients, we will provide pathophysiological insights and practical in vitro assays to guide development of therapeutics for these challenging diseases, which remain among the leading causes of morbidity and mortality in the United States and around the world. Astrocytes are a major cell type in the brain long thought to be passive support cells, but our recent studies have shown that astrocytes powerfully control the formation and function synapses in the brain.
In this research we will test the hypothesis that the superior cognitive abilities of humans compared to rodents is, at least in part, the result of an evolutionary increase in the ability of human astrocytes to control synapse formation and function compared to rodent astrocytes. Telomeres comprise DNA sequences at the ends of chromosomes which shorten by about base pairs per year on average in humans due to oxidation and incomplete DNA replication during the cell cycle.
When telomeres become critically short, chromosomes form chromosome-chromosome fusions which can lead to cancer, and the exposed chromosome ends are recognized as double-stranded breaks that activate DNA damage repair responses that lead to cell death or senescence and consequent tissue and organ dysfunction.
Long telomeres protect the ends of chromosomes, and in our laboratory we have shown that short telomeres make the difference between a fatal and non-fatal muscular dystrophy. Thus, there is a strong motivation to develop methods to safely extend telomeres. We propose to overcome current limitations in telomere extension with two high-impact and broadly-applicable tools: We will demonstrate the efficacy of these tools in cells from human Duchenne Muscular Dystrophy patients.
Our ultimate goal is to develop telomere extension as a therapeutic tool to help prevent, delay, or treat the many diseases in which short telomeres play a major role.
In the United States, more than , patients receive general anesthesia daily to safely undergo most surgical and many non-surgical procedures. Use of anesthetic drugs by non-anesthesiologists in intensive care units and outpatient settings continues to grow. At the same time, anesthesia-related morbidity, including intra-operative awareness, altered neurological development and delirium in children and cognitive dysfunction in the elderly remain significant problems.
Despite the central role of anesthesiology in modern healthcare, research in this field is overly focused on deciphering the anesthetic and toxic mechanisms of current drugs with no attention to developing new approaches.
We propose to redesign general anesthesia by combining optogenetic, electrical and pharmacological manipulations in rodent models to create this behavioral- physiological state through precisely timed control of specific brain circuits. If successful this research will provide a new fundamental understanding of brain arousal control, and eventually, new anesthesiology practices including: Each year approximately three quarters of a million Americans will have a new myocardial infarction MI , and approximately half a million will have a recurrent MI.
No current therapies exist that directly address the negative left ventricular remodeling process that occurs post-MI and results in heart failure. There is therefore a strong clinical need to develop novel therapies to treat MI. This research program will establish a new paradigm in the design of treatments for healing heart tissue post-MI.
Specifically our plan is to develop self-assembling materials programmed to form a healing scaffold in damaged heart tissue immediately following MI. In the proposed, unprecedented approach, the materials will be designed to be injected intravenously rather than directly into heart tissue, and will target and self-assemble in the MI, providing a scaffold to recruit endogenous cells for cardiac repair.
This research proposes to change the current approach to understanding the molecular basis of memory. Our approach challenges the current focus on quantitative identification of synaptic RNAs by developing new technologies to address protein synthesis-dependent synaptic plasticity: These will allow us to redefine the problem from two new superimposed perspectives: Specific synapses will be studied: These complexes will be compared with a delineation of all ribosome-mRNA synaptic complexes present in the same dendrites, allowing us to validate interactions by identifying translationally regulated synaptic mRNAs synaptic translational profiling.
Regulated dendritic RNAs will be further validated by assessing for their translational state in well-studied paradigms of protein synthesis-dependent synaptic plasticity. Psychiatric disease represents the leading cause of disability both in the U. In general, achieving high-resolution information on any biological system typically comes at the expense of the global perspective that is often essential to understanding. This research project will directly address this challenge, in part by developing and applying new chemical engineering-based technologies to rapidly transform intact, impermeable and opaque biological tissue into macromolecule-permeable for labeling and interfacing and transparent form.
The CLARITY technology will be developed with compatible readout methods for extracting volumetric activity and tissue history, information which can then be linked to global wiring and local molecular phenotypes obtained from the very same tissue or organism.
The approach will be developed in the vertebrate central nervous system, challenging for its low accessibility and high complexity, but CLARITY is applicable to any biological system including to the human brain and to models of neurological and psychiatric disease.
Recently, an elegant technique was developed allowing for unprecedented control and specificity in mapping the molecular and cellular properties of neural circuits. Some of the most burning questions in the neurobiology of pain, affect and addiction lend themselves particularly well to the implementation of optogenetic neural modulation techniques, yet these still require drastic miniaturization of circuits, power and light sources for full implementation in diverse neuroscience applications.
Enhancer Therapy Grant ID: Current efforts are to determine the biochemical and biological roles of sequence- specific transcription factors and their associated co-regulators at gene-specific and genome-wide scales. This research project will use a combination of biochemical, cellular and genetic model systems are used, incorporating macrophage-specific knockouts, microarray technologies, massively parallel sequencing and bioinformatics approaches, to unravel the contributions of specific factors to the development of specialized macrophage functions in immunity and the pathogenesis of inflammatory diseases.
One of the primary focus areas of our research is working to integrate physiologically relevant sensory feedback with prosthetic limbs. To this end we employ a variety of approaches that interweave disciplines such as electrophysiology, psychophysics, biomedical engineering and cognition. Our research team is composed of an interconnected and communicative network of clinicians, engineers, and scientists.
This helps us to provide pathways from basic science discoveries that can be used to address clinical needs with transition directly to patient care. Pulmonary infections by microorganisms, such as Mycobacterium tuberculosis and Pseudomonas aeruginosa, are annually responsible for the morbidity and mortality of millions of immunocompromised individuals worldwide.
Despite the availability of drugs that successfully eradicate these pathogens in vitro , they are far less successful in vivo. Due to the challenges of working in situ , most studies of infectious disease agents IDA are conventionally performed with representative isolates and imperfect disease models in the laboratory; by necessity, they are highly reductionist. Very few direct measurements of the physiological state of drug-tolerant populations in the host exist, and little is known about which metabolic pathways are actually at play, much less how they change over time in response to co-evolving conditions within the lung.
We will tackle this critical knowledge gap using an approach inspired by geobiology. Geobiologists are experienced in studying the growth and metabolism of microbial populations in poorly accessible natural habitats by combining molecular biology and stable isotope geochemistry. We propose to study IDA within infected lungs using these tools, with the goal of defining the composition, growth rate and metabolism of the microbial community at different stages in disease progression with high spatial resolution.
The onset of distant metastasis marks the stage of cancer progression where the disease is no longer considered curable. Currently, clinicians are unable to determine when metastases have occurred until the cells have colonized one or more distal sites and often affected the function of the effected organ. We propose an early detection system based on developing an implant that would recruit metastatic cancer cells and a sensor to identify when these cells have colonized the implant.
Recruiting the metastatic cancer cells would initially function to reduce the burden of circulating tumor cells and limit their colonization in other tissues. Investigating the design of implants that recruit metastatic cancer cells is expected to further define the biology of the pre-metastatic niche.
Taken together, the development of an implant to recruit metastatic cells and a non-invasive technology to monitor growth could transform current clinical approaches to cancer treatment. With nearly 15 million units of red blood cells RBCs transfused to about 5 million patients in the U.
During hypothermic storage, a significant fraction of stored RBCs becomes irreparably damaged and the storage medium accumulates known mediators of toxicity as byproducts of RBC metabolism and degradation. The goal of this project is to develop technology for high-throughput removal of irreparably damaged cells and toxic mediators accumulating in the storage medium from RBC units during the transfusion process.
In this project, we will systematically explore the design of smart nanobjects able to transduce molecular level sensing of indicators of health status a. Our results will lay groundwork for broadly applicable families of theranostic providing therapy upon diagnostics devices that would be able to autonomously monitor and correct disease states.
All mRNA molecules are subject to posttranscriptional gene regulation PTGR by hundreds of RNA-binding proteins RBPs involving sequence-dependent modulation of splicing, cleavage and polyadenylation, editing, transport, stability, and translation. The major goal of this application is to identify and characterize the interaction network of mRNA-binding transport and shuttling proteins at the sequence, structural, and functional level and to establish theoretical and experimental models that relate these features to RNA transport processes and PTGR.
Our approach involves deep sequencing methodologies suitable for broadly mapping interaction sites between RBPs and their RNA targets in human cells, followed by integrated annotation of binding sites on transcripts across libraries via a probabilistic graphical modeling approach to identify prevalent states reflecting particular site configurations.
As computed interaction models emerge, these will be studied by biophysical and structural methods using natural, as well as designed RNA recognition element representing RNA ligands together with their respective recombinant proteins. We anticipate the identification of numerous important regulatory regions in mRNAs, as well as uncover mRNAs and RBPs particularly vulnerable to mutation and deregulation in disease states. The role of the innate immune system in aging and AD has received limited study and is poorly understood.
This is due in part to confusion regarding microglial cells and how they relate to the peripheral innate immune system. This advance presents a unique opportunity to determine the functions and dysfunctions of innate immune cells in brain aging and the development of AD. We will study the innate immune system both in animal models and aging human subjects and in human postmortem tissue.
The existing health care system requires an individual to visit a health care facility to conduct point-in-time tests to monitor even the most basic health status markers, which can miss fluctuations in body chemistries that are vital to accurate diagnoses, particularly in high-risk populations. Continuous multi-chemistry health sensors have the potential to dramatically change health care by paving the way for decentralization of health care delivery and shifting the focus away from reactive treatment to preventative maintenance.
We propose to transform current testing paradigms by developing highly miniaturized, injectable, sensors for continuous and simultaneous monitoring of multiple body chemistries. Sensor molecules that glow somewhat like fireflies when they come in contact with certain biomarkers are embedded into specially engineered tissue-like biomaterials. The sensor molecules are embedded in soft, tissue-like biomaterials that become part of the tissue in which they are injected, and do not cause the typical foreign body rejection response.
The sensors are injected under the skin and monitored optically using a miniaturized, wireless, Band-Aid-like reader for continuous measurement or a hand-held wand for periodic self-measurement, depending on the clinical need. The data may be viewed via cell phone or at a remote location, allowing the individual, physician, or other care providers to access medical data without the need for in-person examination until a critical threshold is met.
The research project will develop a systematic in vivo discovery approach for identification of critical genes and pathways that limit the anti-tumor activity of cytotoxic T cells.
Our hypothesis is that shRNAs which target critical inhibitors in dysfunctional T cells can reprogram them to undergo substantial expansion in tumors. T cells will be genetically modified with shRNAs and then transferred into tumor-bearing mice so that enrichment of particular shRNAs within tumors can be quantified.
This in vivo approach will also be used to address a second related problem in oncology, the identification of combination therapies that act in a highly synergistic manner on defined cellular pathways. The therapeutic activity of these human T cells will be tested in a xenotransplant mouse model on human melanomas, as a key step towards translation of our discoveries into the clinic.
Figure describes a device that can manipulate small model nematodes worms in fluidic micro-channels. Populations of worms are treated with different drug compounds and then monitored for health of their entire nervous system at ultra-high speeds. This device will enable the discovery of new drugs to delay or prevent the progression of neurodegenerative diseases and aging.
Neural activity is recorded from channels distributed across two microelectrode arrays implanted in the premotor and primary cortex. Data are decoded in real time to control the cursor. Image shows a sirtuin enzyme catalyzing the removal of a protein modification lysine succinylation from metabolic enzymes. This activity is required for the malignant growth of cancer cells. Small molecule inhibitors of the desuccinylation process may be a novel way to treat cancer. Image shows a schematic of genes being modified from bacteria, and then inserted into human immune cells.
Image shows microscopic circuits that will enable monitoring of the brain's electrical activity using magnetic imaging techniques such as magnetic resonance imaging MRI. Following injection into brains, the microdevices shown in green will convert neuronal voltage signals into tiny magnetic fields shown in dashed blue lines that will be detectable by MRI. Some of these memory T cells migrate into peripheral tissues, including skin, lung, and gastrointestinal tract, and become resident long-lived memory T cells TRM that protect against infection.
Figure illustrates the key components of an innovative and non-pharmacologic treatment for Attention Deficit Hyperactivity Disorder ADHD that combines cognitive and physical exercises. Part of the figure shows a child sitting at a classroom computer and doing one of the cognitive exercises. A second part of the figure shows a group of children engaged together in a group physical exercise in the gym that requires ball skills, concentration and memory. Last part of the figure shows a brain.
Color-coded reconstruction of three pyramidal neurons in the mouse brain. There are a number of axons making synapses on the beige neuron. Synapses are the sites of communication between neurons. Small, round particles, on the order of 10 microns, can be mixed with stem cells of the same approximate size to form aggregates of the cells and materials. As stem cells secrete growth factors, the entrapped particles can capture the secreted molecules. The aggregates can then be disrupted in order to retrieve the particles, now loaded with the stem cell-derived factors.
The stem cell factor-laden particles can then be injected at different sites of disease or injury in adult mammals in order to promote tissue repair and regeneration. Image displays a high-resolution, high magnification electron micrograph of mitochondria isolated from heart. For high sensitivity and specificity in tumor detection, this system is equipped with 4 input channels, shown in 4 panels: Image shows a mesenchymal stem cell MSC on the bottom of the figure transferring red-dye labeled pieces of RNA into a target neuronal cell blue arrow.
African trypanosomes are blood-borne parasites that use their surface coat as a decoy to trick the immune system into making long-lasting antibody responses. Image shows trypanosomes surrounded by immune cells B cells. Trypanosome coats will be modified shown in the middle panel to trick the immune system into making therapeutic antibodies against disease-associated targets inserted epitope, shown in the right panel.
Spina bifida is shown on the left, in magnetic resonance imaging MRI , showing the open spine and exposed spinal nerves arrow.
This and other Neural tube defects NTDs are due to a complex interaction of genetic predisposition and environmental factors, including the addition of methyl groups to DNA. A major source of methyl groups is the vitamin, folic acid. Such maps from patients with spina bifida will be compared with healthy controls to determine which genes are under- or over- methylated in affected patients and could contribute to their risk of having an NTD.
Structure of a Membrane Protein in a Lipid Membrane: Direct Conversion of Fibroblasts into Neurons: Microbes that cause disease are becoming resistant to antibiotics faster than we can find new ones, making many common infections untreatable and life threatening.
Innovative approaches are urgently needed to speed up the discovery of new anti-infectives. This project aims to achieve a paradigm shift in antimicrobial drug discovery by finding next generation anti-infectives that prevent disease by blocking pathogen adaptation to host physiology. Rather than simply preventing bacteria from growing, these new sophisticated drugs will prevent disease by interfering with a microbe's ability to interact with the human body. The findings will help to identify drugs that cure otherwise lethal infections.
A current paradigm in biology is that basal cells present in the epithelial lining of some organs never come into contact with the inner luminal side of the organ. They will take this work one step further and create new model systems to determine the 3-D relationships and functions of different epithelial cell types as the basal cells detect and respond to various drugs, hormones, chemicals and pathogens that appear in the cavity of the organ.
A better understanding of how these novel basal cells communicate with adjacent cells will help define disease mechanisms and suggest new diagnostic and therapeutic strategies for male infertility, and diseases of the lung, including asthma, chronic obstructive pulmonary disease COPD and cystic fibrosis CF.
High-throughput assays are indispensable for comprehensive functional proteome research. To accelerate research in this field, new protein capture tools for the detection and identification of specific proteins are needed. The reagents must be stable to thermal and proteolytic degradation, have high affinity, be easy to produce and present low cross-reactivity.
This proposal presents an innovative approach for screening and selecting a new class of highly stable protein capture reagents and developing a new versatile approach for ligand immobilization that together enable rapid production of cyclotide-based microarrays for proteomics research. These technologies have the potential to accelerate science discovery and to realize the diagnostic and prognostic benefits of clinical proteomics.
Mitochondrial dysfunction has been associated with many diseases, including neurogegeneration, diabetes and cancer, although its exact role in the development of these diseases remains controversial. This proposal tests the paradigm-shifting hypothesis that mitochondrial-derived proteins MPDs play a previously unappreciated role in the regulation of cellular and organismal function, and that disregulation of MDPs is important in disease development.
Understanding the role of MPDs may lead to development of new therapeutic and diagnostic targets. This project aims to develop a revolutionary screening platform that will allow for the rapid isolation of hundreds of high affinity and specificity synthetic ligands for proteins in a highly parallel fashion.
The identification of large numbers of protein ligands is a high priority for biomedical research. Such ligands could be employed as reagents to construct tools for the discovery of diagnostically useful disease biomarkers.
They could also serve as drug leads for a variety of therapeutically interesting targets. Because the ligands will be peptoids, which can be easily synthesized in large quantities by research laboratories lacking specialized organic chemistry skills, the ligands will be more widely accessible to the research community than would be most other classes of protein binding-molecules.
The use of RNA interference RNAi based gene silencing holds great promise as a clinical therapy for many diseases, but such applications face many hurdles including reliable methods for delivery to target tissues and organs.
The investigators have developed a novel microparticle technology for oral RNAi delivery to macrophages in living animals and demonstrated in vivo gene silencing and amelioration of inflammation. They now propose to develop this method as a clinical strategy for treating a number of important diseases in which macrophage-mediated inflammation plays a role including type 1 and 2 diabetes, atherosclerosis, arthritis and inflammatory bowel diseases.
Most of our current understanding of signal transduction pathways relies on solution biochemical analyses of protein interactions and on bulk measurement of select pathways averaged over large cell populations.
This is a proposal to establish a new paradigm for the study of cellular signal transduction that combines biosensor design and live cell imaging to produce a transformative approach to studying cellular signal transduction and decision processes. These advances promise a breakthrough in our ability to probe complex, spatially and temporally organized signaling processes in cell models of normal and diseased physiology. A fundamental property of the brain is that our experiences cause modifications in the number and strength of the connections among neurons.
These changes, which are thought to underlie memory and cognition, require the precise control of the synthesis of specific proteins at the sites of these connections. The mechanisms governing this local synthesis of synaptic proteins are poorly understood, although it is known that disruption of this process has severe consequences. This defect is thought to be responsible for Fragile-X syndrome, the most common inherited form of mental retardation. This proposal describes a method that can provide individual reporters of the regulation of protein synthesis for each gene in the genome, and can identify the regulatory mechanisms controlling each one.
The work will be conducted in Drosophila although the high degree of conservation of gene regulatory mechanisms and function, is it likely that much of what we learn will be transferable to humans. The success of artemisinin-based combination therapies in combating Plasmodium falciparum malaria has inspired calls for the eradication of this devastating parasitic disease.
However, new reports of emerging artemisinin resistance, and the absence of alternative first-line drugs, highlight an urgent need for new control methods. Exploiting the dependency of fatty acid synthesis by liver stage parasites, they will develop fatty acid synthesis-deficient, genetically-attenuated parasite vaccines that arrest in the liver, causing a host immune response that protects against infectious challenge. In addition, they will target parasite synthesis as well as salvage of host fatty acids, as a means to develop novel prophylactic and curative medicines that can prevent and control this widespread and devastating disease.
A tremendous gap exists between available culture and animal models and methods that can extract detailed information on cell-cell communication networks governing system responses to perturbations, such as an inflammatory cue.
Networks inherently operate in a complex, interlinked fashion, and often exhibit non-intuitive outcomes from intervention at a particular point in the network, as evidenced by failure of many targeted therapeutics to operate in the clinical setting after promising results in currently- available preclinical trials.
The goal of this project is transform our ability to probe cell-cell communication networks in human cell systems via linking systems biology with tissue engineering. Development of new methods that do not rely on genetic manipulation of the cell populations will generate valuable information about systems operation.
A central paradigm of medical genetics is that the phenotype of a deletion syndrome results from the disruption of the deleted genes themselves. In direct contradiction to this dogma is the idea that genetic diseases can be caused or modified by changes in physical, long-range interactions that normally occur between loci that are now deleted and genes that are far from the deleted region when plotted on a linear genetic map.
In some cancers and genetic diseases, long range associations between genes are lost because a part of a chromosome becomes deleted. By examining the network of long range interactions among genes, we will learn how diseases are caused by the change in the expression of many genes which become abnormally regulated when the interactions are lost. This project seeks to address the mechanisms underlying the integrity of tissues, networks of interacting cells and matrices. The project will determine how cells come together to form tissues, and test the hypothesis that tissue integrity results from the integration of information that arises from the dynamic interactions between the different cell types and the matrices that bind these cells together.
Using the filtration barrier of the kidney cortex as a model system, the researchers will apply a combination of mathematical models and engineering approaches to develop a 3-D tissue assembly to study this phenomenon. These studies will identify general design principles for assembling functional tissues that can aid in understanding disease processes and for screening for new drugs. The detection of proteins is fundamental to essentially all biomedical research.
Current strategies to detect proteins include techniques such as Western blotting and enzyme-linked immunosorbent assays. Currently, there are no techniques that permit the levels of endogenously expressed proteins to be monitored in real time in living cells. The sensors will be used to monitor protein expression in cells in real time. The experiments will result in powerful new tools for protein detection that will markedly enhance and expand biomedical research.
More than 30 million Americans suffer from unrelieved chronic pain, such as nerve injury-induced neuropathic pain. Although a considerable amount is known about how chronic pain is induced, little is known about how acute pain naturally resolves. Current management of chronic pain mainly focuses on two types of drugs, ones that treat pain symptoms by blocking neurotransmission and those that modify disease progression by suppressing neuroinflammation.
This project employs a novel approach for chronic pain therapy using newly uncovered endogenous pro-resolving lipid mediators. The project will investigate whether and how these mediators can prevent and reverse neuropathic pain after nerve injury. The results from the proposed studies are likely to transform and positively impact on the entire pain community, from acute postoperative pain to chronic inflammatory and neuropathic pain. Protein-capture reagents are indispensable for delineating the molecular mechanisms of diseases, to detect and characterize cellular abnormalities, and to characterize biological effects of drugs.
However, the current paucity of high-quality protein-capture reagents presents a major bottleneck in virtually all areas of biomedical sciences. This project will establish a totally new approach to facile generation of detection reagents that are high performance, easy to produce and easily made available to the research community. This innovative and powerful technology will fill a major void in the currently available molecular tools and will have a major impact on virtually all areas of molecular biomedical sciences, diagnosis and drug development.
The adult human intestine performs essential roles in physiologic homeostasis including digestion, nutrient absorption, secretion of hormones, and immune functions. Diseases of the intestine, such as inflammatory bowel diseases, infection, malabsorptive states and neoplasia, are a considerable source of human morbidity and mortality. Human primary intestinal culture is essentially not utilized as an experimental tool because primary tissue types lack appropriate in vitro culture methods.
To meet this need, this project proposes to employ an innovative approach to enable the primary culture of three-dimensional 3-D human intestinal tissue, which is currently not possible. The ability to reproducibly culture 3-D tissues outside of the body will enable scientists to test new hypotheses and models of physiology and disease, to develop high-throughput screens of pharmaceutical targets, and to enable the expansion of cells for regenerative medicine therapies.
Hepatocyte transplantation has been reported as a possible therapeutic approach for liver disease; however, transplantation has been directed at the liver itself, limiting efficacy in patients with end-stage liver diseases, when cirrhosis and fibrosis are common. This proposal will demonstrate that the generation of an ectopic liver within lymph nodes is an efficient method to restore hepatic function, highlighting the novel use of this organ as a site for hepatocyte transplantation.
The project addresses some of the hurdles confronting the development of complex 3-D tissue models, and provides a new paradigm for tissue modeling, by using lymph nodes as in vivo bioreactors to grow tissue or organ substitutes. Nitric Oxide NO is an essential signaling molecule for diverse physiological and disease processes.
While the regulation of NO flux has focused primarily on the study of the three NO synthases NOS , their respective genetic deficiencies exhibit relatively modest phenotypes, which has led to difficulties in dissecting the specific cellular contributions to NO in different disease processes. This project will study a new way that NO production may be regulated in the body by the chemical argininosuccinate lyase ASL which may control the production of arginine needed for NO production. Thankfully Remy did not sustain any injuries and was back in the booth on Sunday.
Michael Irvin joins the cast as guest analyst throughout the season, with Adam Schein also returning to the show as a contributor and guest host. The agreement covers pre-season, regular-season, and post-season games, with extensive pre and post-game shows, producing an eight-hour game-day broadcast.
Costas was able to pull some strings at the MLB network to make it happen. Kevin Calabro has been named the new television play-by-play voice of the Portland Trailblazers starting with the season.
The broadcast veteran takes over for Mike Barrett , who departed the team with color analyst Mike Rice after 13 years. Open is upon us and ASA member Joe Buck will once again man the Fox booth, this time with new partner Paul Azinger , who replaces Greg Norman who was let go after a less than stellar first year on the job.
He will still call college basketball and Masters Golf for the network. To mark the th running of the Indianapolis , ABC is set to utilize cameras for the race, which takes place on May 29th. Production will include three onboard cameras per car in 12 of the 33 cars competing in the race as well as four Ultra Hi Motion cameras, aerial cameras located in a blimp and a helicopter and four robotic cameras with overhead views of the pits.
Sound will be captured for viewers by microphones, including positioned around the racetrack and 26 mounted in race cars. In a move which would be unheard of today, CBS decided to hold an on-air audition between the two heavyweights for the first 8 weeks of the NFL season. In weeks 5 -8, Summerall paired with Madden, and Scully with Stram. By week 9, the showdown between the broadcasting behemoths ended with CBS executives voting that Summerall had the better chemistry with Madden and was a better fit.
Scully, who was upset with the way the situation was handled, eventually left for NBC in to be the No. Of course, Madden and Summerall went on to become one of the best broadcasting teams in sports history. Sager, who has been battling Leukemia since , recently revealed that the cancer has returned for a third time. He has already had two stem cell transplants.
Sager also appeared on the cover of the May 2nd issue of Sports Illustrated that included an in-depth feature article by Lee Jenkins. He will continue to call college basketball after the NFL season. Telemundo and NBC Universo unveiled their agenda for this year's Summer Olympics in Rio, offering more than hours of coverage on the two networks which will rank as the most in the history of US Spanish-language television.
The action begins on Aug. With a spotlight on soccer and other primary targets that include swimming, track and field, boxing, diving, tennis and more. A Lifetime member of ASA, Tirico has been a mainstay at the "worldwide leader in sports" since the early s when he was an anchor on SportsCenter. He has been the play-by-play voice of "Monday Night Football" since Schilling, who started at the network in , said ESPN was "a company where the rules are different based completely and solely on your perspective and your belief.
As long as you're not sleeping with my wife, I don't care who you sleep with," Schilling said. The Facebook post in question, which has since been deleted, showed a man in ripped women's clothes with the caption: President Barack Obama , who will be in attendance, is also making history as the first acting president to visit the country since Calvin Coolidge in Hopefully the mutual love of baseball by the U.
The deal will see TSN serve up expanded pre-race and post-race coverage for all 21 races on the F1 calendar. The Fight Game, which launched in , makes its season premiere on Wednesday, March 16 Dino Costa , veteran sports talker, will be joining St. Two people have since been fired for illegally accessing and leaking the file which was revealed by Schefter after Pierre-Paul's 4th of July fireworks accident.
His first assignment will be on April 8 on FS1. Beginning March 1, the network will offer coverage of every MLB camp with its "30 Clubs in 30 Days," as well as over spring training games. He will make his debut on March 12 with partner Al Bernstein , the first of eight scheduled monthly events known as "Knockout Night at the D.
The first event set to run on FS1 on April Justin Bell and Andrew Marriott report from around the paddock. Jay Bilas , veteran ESPN basketball analyst, was named the recipient of the Curt Gowdy Media Award for his contributions to the sport as a member of the electronic media. Those games will be simulcast on the NFL Network , which will get its own slate of eight games, including late season Saturday games. My, how time flys. Cohn, who made her "SportsCenter" debut alongside Chris Meyers back on July 11, , has hosted more editions of the show than anyone else in its year history.
Fox Sports 1 has decided to cancel its nightly highlight show, "Fox Sports Live. A time table for his return has not been determined. We at the ASA wish him a full and speedy recovery.
It seems to be one and done for Greg Norman. According to reports, Fox has dropped the U. Open golf analyst from its coverage after only one year. It's been rumored that the network, which acquired the rights to the golf championship last year, was unhappy with Norman's lack of preparation and weak analysis during crucial moments of the broadcast.
The Minnesota Vikings suffered a heartbreaking loss to the Seattle Seahawks in the first round of the playoffs, and it seems like no one was more upset then their radio play-by-play announcer Paul Allen. The season can't end like that! Allen then somberly stated, "The Seattle Seahawks are off to Charlotte.
I guess three really is a crowd. FOX also announced that its No. Hernandez, 62, has been a commentator on Mets telecasts on SNY for 10 seasons.
He has been joined by play-by-play announcer Gary Cohen and fellow analyst Ron Darling to form one of the most beloved broadcast teams in sports. CBS Sports is getting a make over. Rachel Nichols is heading back to Bristol. According to reports, the veteran Turner and CNN reporter will be returning to ESPN where she will host her own program, serve as an anchor and reporter, contribute to SportsCenter and other platforms. Spanish-language rights to the World Cup away from rival Univision starting with the tournament.
When your phone rings, answer it. Because it might be living legend Vin Scully on the other end. That's what Joe Davis learned when he let two calls that didn't come up on his caller ID go to voice mail. The first call ended with no message but the second left Davis in awe, as it was broadcasting great Vin Scully welcoming the year-old to the Dodgers family.
The up and coming Davis has already worked for ESPN and Fox Sports, and with Scully announcing that will be his last year, there is speculation that Davis will be groomed to be the next Dodgers voice. He will have some mighty big shoes to fill. As he announced that he will be leaving the position he has held since at the end of the year. The move came as a surprise to the boxing world, as Hershman, 52, is one of the most powerful people in the business. He handled an eight-figure annual budget for HBO's boxing franchise, oversaw its pay-per-view division and decided which fighters the network would back and hopefully propel to superstar status.
With college hoops about to get into full swing, ESPN has shored up its broadcasting crew across its college platforms. The season gets underway across the networks on Friday, Nov. Next season, Cervasio will anchor a Cosmos pregame show and report from the sidelines, joining play-by-play man JP Dellacamera and analyst Shep Messing. Unbeknownst to Breer and Jones, some of his teammates were in the background in their birthday suits, which probably won't "sit" well with the FCC.
I'm sure this will rehash the ongoing debate as to whether or not cameras and the media really need to be in the locker room. At least it wasn't a female reporter, which would have opened up a whole other can of worms.
No wonder why Alex Rodriguez doesn't play the field anymore, he's lost his throwing accuracy. A former quarterback in high school, A-Rod was prompted to show off his arm and proceeded to sail a pass over the head of NFL insider Jay Glazer that went crashing through a TV monitor. Sager, who recently received another round of chemotherapy in his ongoing bout with leukemia, will work the Pelicans-Warriors game with the broadcast team of Marv Albert and Chris Webber.
Joe Buck has apparently upset some Kansas City Royals fans, namely Adam Jones , who started a petition to have the longtime Fox play-by-play man relieved from his duties calling the American League Championship Series. Buck caught wind of the petition and even had a little fun on Twitter, retweeting the link and offering "Good Luck" to its creator. Jones should be happy, his Royals are up two games to none on the Blue Jays. I don't think Michigan reporter Jamal Spencer is familiar with the late Yogi Berra saying, "It ain't over 'till it's over.
The mistake was corrected by the sports anchor back in the studio and the station manager also offered an explanation on their website. Martin will make her network debut on Oct. Although it has not been finalized, sources say Harrelson, 74, will only work road games and a limited number of home games including Opening Day and the Chicago Cubs series.
Vin Scully , legendary LA Dodgers voice and ASA Hall of Famer, announced that he will be back for a record 67th season behind the microphone in , but the broadcasting icon said it will likely be his last Jessica Mendoza made history on August 24 when she became the first woman to broadcast a major league baseball game on ESPN.
Ian Eagle and Dan Fouts take the No. Speaking of Cowherd, Fox Sports officially announced that his new radio show will air from 12pm-3pm on Fox Sports 1 and Premiere Radio.
Doug Flutie , NBC college football studio analyst, will be moving into the broadcast booth this year, replacing Mike Mayock on Notre Dame football telecasts. Mayock had been the calling Fighting Irish games since Replacing Flutie in the studio will be former Saints linebacker Jonathan Vilma. Bill Simmons , sports commentator and writer who recently parted ways with ESPN, has signed a multi-year deal with HBO where he will host a weekly television series.
The show, which will feature stories and guests from across the sports and other landscapes, will debut in Van Miller , legendary voice of the Buffalo Bills for 37 seasons, died on July 17 after a brief illness. Unfortunately, the team was unable to capture the Lombardi Trophy. The move comes after Donovan McNabb , who was tabbed to call NFL games for Fox this fall, was suspended indefinitely by the network after his recent DUI arrest, the second in 18 months.
With Davis headed to the pros, Fox announced that Joel Klatt will take his place as lead college football analyst. Hellums worked alongside eight play-by-play announcers and broadcast over games. His last game was Nov. Ley, who joined the fledgling network on September 9, , its third day of operation, will continue to host Outside the Lines and numerous soccer events including the World Cup and Euros Dwayne Wade may be looking towards life after basketball. Sports Illustrated has reported that Bill Simmons will no longer participate on any ESPN platforms despite several months remaining on his contract.
According to the article, the two sides have reached an agreement that will keep Simmons off the air as well as away from his site Grantland and podcasts. In addition, Marks is slated to provide SportsCenter updates regularly on weekdays and host or co-host multiple shows as needed. ESPN has secured a deal with the Mountain West Conference to bring its annual football championship game to the network through the season.
The Mayweather camp has denied these allegations, saying there was a mixup at the credentials office and the two veteran female reporters were never banned from the event. NBC Sports has been offering a record The Baltimore Orioles , playing for the first time since the outbreak of riots in the city several days ago, beat the Chicago White Sox , , in an afternoon game played at an eerily silent Camden Yards that was closed to the public due to safety concerns.
This is the first time in major league baseball history a game has been played where fans were not allowed in the stadium. The O's are scheduled to hosted the Devil Rays but the series will be moved to Tampa with Baltimore assuming the role as the home team.
The network said they did not need permission from major league baseball to hire Rose, who was banned for life in , but contacted them as a courtesy to alert them they were interviewing Rose and planned to offer him a contract. Open, which he will cover in June. The year TV veteran started his 6pm sports report by thanking viewers for all their support during his month-long recovery.
Stone will anchor coverage of the six-city, month-long tournament from the FOX studio in Vancouver, British Columbia, the network announced Wednesday. Our sympathies go out to John Sterling , New York Yankees radio announcer, who was among the hundreds of people who lost their homes during a multi-alarm fire that raged through the The Avalon apartment complex on January 21st in Edgewater, NJ.
Thankfully there were no casualties, as over people were safely evacuated. The move should not affect his work as the analyst on Cowboys radio broadcasts. Laufenberg completed his 22nd season with the Cowboys on Sunday. Broadcast team Joe Angel and Fred Manfra will return for their 12th season together. Louis Cardinals games alongside play-by-play man Dan McLaughlin. Let the pictures speak for themselves. The Giants Win the Pennant! Does the booth have a good phone line? Are there enough electrical outlets to accommodate all your electronics or do you need a surge protector?
Are stats and rosters readily available? Broadcasters are also encouraged to post photos and reviews of the booths they've worked in.
The deal will take effect starting with the season and run through the campaign. The new deal will also result in a substantial increase to team salary caps, which NBA superstars LeBron James and Kevin Durant will look to take advantage of when they are eligible for free agency in Kobe Bryant has also commented on the mega deal, tweeting that the additional income means owners can no longer call players selfish and ungrateful for not wanting to take less money for the good of the team.
Robinson will also undergo sensitivity training. He has since apologized for his comments. Here's what Raissman had to say: While others have gotten extremely windy stating their positions, Gumbel said, 'I haven't used it the name for a few years. It's just that I didn't feel that you need to stand up on a podium and announce it.
It's what makes him different than most of his peers. Tom Durkin , longtime horse racing announcer, retired after an illustrious year career which included 20 years as the voice of the Breeders' Cup, and 10 years of calling the Triple Crown races on television. Tappen will continue to appear as a personality on the NHL Network as well.
Brando will cover college football and basketball for Fox Sports and Fox Sports 1 beginning this Fall. Brando's partner and the rest of the broadcast roster will be announced at a later date. Mike 'Doc' Emrick , who will miss Game 1 due to a death in his family, will return for the remainder of the series beginning with Game 2 on Saturday.
Game two has also shifted to NBC,airing at 7: Games three and four will be carried by NBCSN while any of the potential final three games will run on the broadcast network. Production highlights are set to include an updated broadcast open celebrating the greatest players and moments from the NBA Finals; I-MOVIX cameras presenting slow motion replays; 36 high-definition video cameras; and the use of eight Super Slo Mo cameras.
Jenny Dell , NESN reporter whose role was significantly reduced in January when she let it be known she was romantically involved with Red Sox third baseman Will Middlebrooks , is leaving the network. Coverage includes the June 4th documentary, "California Chrome: Coverage of the Belmont Stakes begin at 2: The year veteran who played his entire career with the New York Giants, announced his retirement in January.
Our thoughts and prayers go out to Sager and his family during this difficult time. He also hosts a weekly coaches radio show on WADI NBC had broadcast the tournament since Hall of Fame broadcaster and ASA member Milo Hamilton was behind the microphone to provide the call for this monumental event in baseball history: That is ball is gonna be-eee … Outta here! Brian Billick will not be returning to Fox Sports after the network decided not to offer the NFL analyst an extension to his expiring contract.
Mary Carillo agreed to a three-year contract extension with the Tennis Channel through Carillo originally joined Tennis Channel in The first episode will debut on Tuesday, March 18 at 7p and feature Orel Hershiser.
Mike Schmidt it returning to the Phillies, where he will join Comcast SportsNet as a member of the club's broadcast team for 13 Sunday home games in Schmidt will work as an analyst alongside play by play man Tom McCarthy for Sundays with Schmidt broadcasts this season. Curt Schilling , ESPN baseball analyst who announced last week that he has cancer, underwent surgery and is recovering, according to his daughter, Gabby.
The year-old has not divulged what type of cancer he has. Schilling, who pitched in the majors for 20 seasons, was recently added to the "Sunday Night Baseball"announcing team, replacing Orel Hershiser. The network reports that As for the Pepsi Halftime Show, The four-time Super Bowl champion flew back to Louisiana to be with his family during this difficult time. He will serve as curling analyst for NBC Olympics' coverage. In her first interview since deciding to withdraw from the Sochi Olympics, Vonn appeared on Today this morning to talk about her role at the network and give an update on her training and rehabilitation before talking about how athletes prepare physically and mentally for the Games.
Facing stiff competition from the Grammys, the game averaged a 3. I think the players played much harder. According to the official release from the BBWAA, the Board of Directors also decided to remove Le Batard's membership for one year, for "transferring his Hall of Fame ballot to an entity that has not earned voting status.
Michaels has also covered numerous Olympics including his unforgettable broadcast in of the United States' hockey team's gold-medal run at the Lake Placid Games when he made the memorable call of "Do you believe in miracles? Bob Wolff , the longest running broadcaster in television and radio history, celebrated his 93rd birthday on November Brian Wheeler , ASA member and Portland Trail Blazers radio play-by-play announcer, had his broadcasting streak of 1, consecutive games snapped on November 15 when he missed his first game a win against the Celtics in Boston in his year career with the Blazers due to illness.
Last week the Blazers announced that Wheeler would not be accompanying the team on their four-game road trip with stops in Boston, Toronto, Brooklyn and Milwaukee. Raftery said he will call somewhere between games this season for Fox Sports 1. I prefer to skip it. The Titans ended up winning by an even larger margin, Kellogg was a studio analyst for 16 years before replacing Billy Packer on game telecasts.
He called his first Final Four in Although the move to CBSSN would give the show national exposure, the content, which has a New York flavor, might need to be changed to appeal to a wider audience. Marty Brennaman , Hall of Fame broadcaster, has agreed to a three-year contract extension with the Cincinnati Reds to continue as their play-by-play announcer on Radio Network through the season.
Brennaman, 71, has been the radio voice of the Reds since joining the team in Frick Award in Next year will mark his 50th as a baseball broadcaster.
The fast-paced, upbeat sports talk show features sports superstar guests who share real-life stories. I look forward to continuing to offer compelling stories and informative interviews for our ever-expanding audience with some of the biggest names in sports.
The former co-host of WFAN's "Mike and the Mad Dog" will host a weekday television show and appear on other programs the network produces. Russo will also continue to do his "Mad Dog Unleashed" show on SiriusXM, as he recently inked a new three-year deal with the satellite radio provider. Bob Robertson , voice of Washington State University football for 46 years, has announced he will be stepping down effective immediately. Bud Nameck , WSU's basketball voice and football sideline reporter and part-time analyst, will be taking his place.
WSU athletic director Bill Moos called it a mutual decision. Robertson will continue to work the pregame and postgame as well as halftime shows. Socci will replace the legendary Gil Santos , who retired following the AFC Championship game in January after 36 seasons as the voice of the Patriots. Socci has called Navy Football for the last 16 years and had a short stint with the minor league Pawtucket Red Sox before getting the call for the Patriots gig.
Just last week, the network acquired the rights to the U. The award will recognize the strength and courage Roberts has displayed throughout her life and career, overcoming life-threatening illnesses twice. Actually, I was praying myself. There was very little you could add. This will be the last on ESPN, which has aired the tournament since The Big East basketball schools, including St. This will be Ashby's second stint in the broadcast booth for the Astros, previously working the radio side.
Ashby will primarily do color for the Astros, but he's expected to do some play-by-play as Brown, 65, is reducing his play-by-play duties to about games. The bulk of the ABC show turned into a celebration of her return as she's recovering from MDS, a blood and bone marrow disease. Leigh Diffey has joined NBC Sports as the lead play by play announcer for the network s auto racing coverage. She is a graduate of Arizona State University.
The passing of longtime Los Angeles Lakers owner Dr. Jerry Buss has sent shockwaves throughout the City of Angels. Best known in his playing days for his devastating forkball, the right-handed pitcher and five-time All-Star will forever be known to Blue Jays fans as the first game winner in club history 21 wins and for propelling his team into the playoffs for the first of their back-to-back World Series Championships in and Morris retired in and has spent time as a color analyst for the Minnesota Twins and as well as a guest on Detroit Tigers broadcasts.
Louis resident, paid tribute to the late Stan Musial during a two-hour mass outside Busch Stadium on Saturday, January 26th. Stanley Frank Musial made a name for himself as one of baseball's best hitters of all time on the field, as well as one of its greatest, most dignified ambassadors off it. And now "Stan the Man" is gone. Musial died at his Ladue, Missouri, home surrounded by family, the Cardinals said in a statement.
Croix County Court in Wisconsin, 30 miles east of Minneapolis. John Andariese , longtime New York Knicks TV and radio announcer, was honored with the fifth annual Dick McGuire Knickerbocker Legacy Award , given by the family of the Hall of Fame player and team employee to a person who "exudes the qualities of what it means to be a Knickerbocker.
I completely understand how the issue of race in sports is a sensitive one and needs to be handled with great care. This past Thursday I failed to do that. The failure was in how I chose to discuss it on First Take, and in doing so, turned a productive conversation into a negative one. Perhaps most importantly, the attention my words have brought to one of the best and brightest stars in all of sports is an unintended and troubling result.
As I reflect on this and move forward, I will take the time to consider how I can continue to tackle difficult, important topics in a much more thoughtful manner. Larry Merchant , longtime boxing Analyst for HBO Sports, stated that he is retiring from ringside as of Saturday December 15th, when he will work his last fight. Yankee Global Enterprises would retain a significant minority stake.
Plesac was considered a frontrunner from the moment Brenly announced he was returning to the Arizona Diamondbacks to work a reduced schedule on Fox Sports Arizona and national games for Fox Sports. The show, which debuts earlier than any other Sunday NFL pregame show at 7 a. Chitwood steps into the spot vacated by J. Many great quotes are attributed to the man, one of the most fondly remembered of which had nothing to do with football.
In , as American hostages were freed from Iran and baseball commissioner Bowie Kuhn offered them lifetime passes to major league games, Cook asked: Alex Karras , former defensive tackle for the Detroit Lions, actor in movies and TV as well as the third-ever analyst on Monday Night Football, died on October 10 at the age of Karras had recently suffered kidney failure and been diagnosed with dementia. And was being cared for at home. Karras was considered one of the best players in Lions history having played from Karras stayed with MNF through the season.
Karras also had a number of movie and TV roles. Frick Award , presented annually for excellence in baseball broadcasting by the National Baseball Hall of Fame and Museum for full story see News.
ESPN Radio lined up its announcers for the coming playoffs, which marks its 15th consecutive season as the exclusive national home of the Major League Baseball postseason. NFL Films President Steve Sabol , half of the father-son team that revolutionized sports broadcasting and mythologized pro football into the country's favorite sport, died Tuesday from brain cancer.
For full story see In Memoriam Allen Pinkett , Notre Dame football radio analyst, will not broadcast the Irish's game on Saturday, Sept 1st, against Navy in Dublin, Ireland, because of the controversial comments he made during a recent radio interview.
They would have two or three guys that were criminals. That just adds to the chemistry of the team. I think Notre Dame is growing because maybe they have some guys that are doing something worthy of a suspension, which creates an edge on the football team.
You get your butt kicked if you have a team full of choir boys. You gotta have a little bit of edge, but the coach has to be the dictator and ultimate ruler. Musburger, 73, remains one of the most visible play-by-play announcers on broadcast television. CBS Sports announced its NFL broadcast pairings for the season, with the only change from last year being the elimination of the No. With the NFL having Thursday night games all season long, the Sunday afternoon carriers, including Fox, need no more than seven broadcast teams on any given week.
Vincent Coughlin and Chris Paizis both 21, will work the home games while David Rind , 22, will broadcast games on the road. LeRoy Neiman , who stood alone among contemporary artists in capturing the color, spectacle and excitement of the world of sports, died one June 20, Fusselle, a sportscaster for over 40 years, most recently was the play-by-play voice of the Brooklyn Cyclones, a Class A minor league affiliate of the New York Mets.
ESPN's audience has nearly doubled since May , up to 1. Roberts announced Monday morning that she has myelodysplastic syndrome, or MDS, which used to be known as preleukemia. She says her doctors have told her she has a great chance to be cured of the serious medical condition, but that she will miss time on the show as she undergoes treatment.
She will now begin a pre-treatment of chemotherapy in advance of a bone marrow transplant later this year. She says that while bone marrow donors are scarce, particularly for African-American women, she is fortunate to have a sister who is an excellent match.
Roberts has been on "Good Morning America" for a decade, most recently teamed with George Stephanopoulos as co-anchor. On a day some of her bone marrow was extracted for testing, Roberts learned she had landed an interview with President Barack Obama where the president revealed his support for gay marriage.
Beadle is reportedly negotiating a deal with the network, but nothing has been finalized yet. Dom Valentino , longtime sportscaster, died on April 17, , after a bout with prostate cancer.
Steve Fredericks , well-known sports talk show host, died on April 7, , after a battle with pancreatic cancer. The year-old shows no sign of slowing down as he just signed a two-year contract extension with News 12 where he has been since the station launched in NBC previously aired the Breeders' Cup from to Both are longtime ASA members who have given so much of their time and effort over the years in support of the organization and its many endeavors, and we wish them nothing but the best on their road to recovery.
Tim McCarver , an All-Star catcher who discovered a second career as a folksy announcer known for explaining the game in exacting detail, won the Hall of Fame's Ford C.
Frick Award for broadcasting excellence on Wednesday. Frick Award , presented annually for excellence in baseball broadcasting by the National Baseball Hall of Fame and Museum. Vitale, a New Jersey native, got his start coaching high school basketball at East Rutherford and Garfield before moving on to college ball at Rutgers. For full story see Articles In a poll recently conducted by the American Sportscasters Association , its members questioned why sportscasters are not involved in the National Baseball Hall of Fame voting process.
For full story see News. The and seasons will see Miller reach 40 years as "The Voice of the Kings. Vin Scully , ASA Hall of Famer and legendary Voice of the Dodgers, has announced he will be returning for the season, marking an unheard of 63rd year with the team. Scully surprised listeners with good news during the August 26th contest between the Dodgers and Rockies.
I asked him, 'One more year at least? Kenny is also looking for a boxing gig and HBO and Showtime have shown interest. Open champion joined the network this summer at Wimbledon. Former Baltimore Orioles pitcher Mike Flanagan , a Cy Young Award winner who became a television announcer and top executive with the club, died from an apparent self-inflicted gunshot wound Wednesday afternoon, according to police. For full story, see News Howard Eskin , longtime ASA member and sports talk radio pioneer, has decided to step down as host of his daily radio show on WIP in Philadelphia after 25 years effective Sept.
He said he will remain at the station in a different capacity as well as pursue other opportunities. He will make his regular-season "Monday Night Countdown" debut Sept. The show, which debates topics based on fans' suggestions, also will feature Steve Young, the former San Francisco 49ers quarterback who threw 85 touchdown passes to Rice. Nolan and stands in the plaza below Harry the K's restaurant in the left field corner of the ballpark.
Scott, 36, was to be arraigned on second degree rape charges but in a plea agreement, was allowed to plead guilty to the misdemeanor charge. Scott left television last year to work as a full-time sports medicine doctor.
Arlin described what he was seeing on the field to those beyond the ballpark as he spoke into a converted telephone from a seat behind home plate at Forbes Field as the Pirates defeated the Phillies, July 2nd marked the 90th anniversary of the first sports broadcast in New York. No longer will American tennis fans have to search for Wimbledon matches on TV.
All England Club officials achieved their goal of having the entire tournament televised live and by the same company in the U. The network will broadcast eight regular-season games starting Nov. In an effort to raise money for this disease, Carrino, 40, has launched the Chris Carrino Foundation for FSHD, which is a genetic muscle wasting disease effecting both children and adults in a variety of ways.
Kiner was part of the original broadcasting team along with Lindsey Nelson and Bob Murphy when the Mets started play in Bob Wolff , the longest running broadcaster in television and radio history, has authored a new book entitled, The Complete Guide to Sportscasting.
Brooks Robinson Baltimore Orioles Hall of Fame third baseman and former Orioles color commentator, was hospitalized after developing a fever and infection before a scheduled outpatient surgery at Greater Baltimore Medical Center on March A release from Robinson stated that his doctors chose to fight the infection and he is responding well to antibiotics.
House of Representatives in recognition of his charitable work and support of the youth in his hometown of Washington, DC. This acquisition represents the largest and most significant collection of sports broadcasts in America. The station also announced it will be giving him a contract extension.
Cantor also has a daily radio program that can be heard in over stations in the U. Are you the next Chicago Cubs announcer? The Cubs announced a contest giving fans a chance to become their next public address announcer at Wrigley Field. The current PA announcer Paul Friedman is leaving the organization to "pursue a new job opportunity" that would keep him from working day games at Wrigley. Fans can submit their audio or video applications to http: Finalists will be selected by March 14, and the winner will be selected March Tommy Hutton , ASA member and Florida Marlins announcer, is celebrating his 30th year in broadcasting and 47th year overall in baseball.
ESPN announced its new lineups for its baseball telecasts. Commissioner Bud Selig made the long—anticipated announcement on Saturday, Feb. Johnson's caddie, Bobby Brown , had the wrong tee time for the opening round, leading to a two-stroke penalty.
Brown said Gray approached Johnson on his way to the 14th tee to ask him why he was late to the tee. As Johnson was signing his card, Brown told Gray that the middle of the round was not the time to be asking such a question.
Anything else is a disservice," Golf Channel spokesman Dan Higgins said in a statement. Fans can share their stories and vote for their favorites at honorarybatgirl. Darryl Strawberry is not even making that much money. Valentine said the new position will not interfere with his baseball analyst duties at ESPN Ron Franklin has filed a lawsuit against ESPN for wrongful termination after the company dismissed Franklin, who had been with the company for 25 years, on Jan.
Please contact the ASA if interested. Frick Award, presented annually by the National Baseball Hall of Fame and Museum for excellence in baseball broadcasting.
He had also been battling emphysema in recent years and suffered a stroke in Meredith led the Cowboys to NFL title games in and , losing both contests to the Packers, before abruptly retiring at age 31 in He retired in , one year after Cosell left the team. Hershiser worked on "Sunday Night Baseball" last season; Valentine, a former player and manager who served as an analyst on ESPN's "Baseball Tonight" last season, joins the booth for the first time. The team replaces Jon Miller and Joe Morgan , whose contracts were not renewed after last season.
Miller and Morgan had been the voices of "Sunday Night Baseball" for 21 seasons. For full story see news Hall of Fame announcer Dave Niehaus , the lead voice for the Seattle Mariners since their inception, died Wednesday, November 10, For veteran analyst Tim McCarver , marks the 21st year he will be providing color commentary for a World Series, a streak that might be impossible to ever match.
He is also approaching his 2,th broadcast as the play-by-play radio voice of the Sacramento Kings. Sports on September 5.
Sugar has written over 75 books, mostly on boxing, and was the editor of Ring Magazine and Boxing Illustrated. Aside from his boxing notoriety, Sugar is also known in the baseball world for his Sports Collectors Bible , a comprehensive reference guide for baseball card enthusiasts, which he first published over 35 years ago. He will serve as a reporter on 20 Kings games this season, as well as cover special Kings events and conduct interviews with high profile figures around the world to be aired on Kings broadcasts.
ASA President Lou Schwartz was also on hand for the festivities and to show support for Miller For Miller's speech and photos from the event see News George Steinbrenner , whose thirst for winning gained him infamy as Yankees owner, died Tuesday, July 13, the team confirmed, after suffering a massive heart attack at his Tampa home.
He was 80 years old. With his contract set to expire in January, Clark said he went to station management and said it was time to go. They offered to negotiate a new deal, but he, with the support of his family, made the decision to step away. This was my decision," he said. Brown called games on television and radio from and He was at the microphone in when the White Sox clinched the AL West title to reach the postseason for the first time since Longtime Detroit Tigers broadcaster Ernie Harwell , beloved by generations of fans who grew up listening to his rich voice, Southern cadence and quirky phrases on the radio, has died after a months-long battle with cancer.
See In Memoriam for full story Hall of Fame boxing referee Arthur Mercante , the third man in the ring for the first Joe Frazier-Muhammad Ali fight and more than a hundred other world title bouts, died Saturday. The cause of death wasn't disclosed. Sports broadcasting and cable pioneer, Chester R. For full story see News ASA Board member Jon Miller , who has spent parts of five decades as the voice of five major league baseball teams, was selected Monday, February 1, as the recipient of the Ford C.
He was 70 years old. Then in it grew into the first nationally syndicated sports highlights show, eventually airing in markets across the country and in 10 foreign countries. It was a trendsetting program, gaining its footing in the days before ESPN and cable television were widely available. Mazer,89, who hosted the first call-in sports show in on NBC Radio, admitted that his hearing has started to falter which prompted him to hang up his headphones. She also won for Outstanding Feature Reporting.
A son of late Braves broadcaster Skip Caray and a grandson of famed broadcaster Harry Caray , Chip had called first-round playoff games for TBS during the past three seasons. Pomeroy said no replacement has been picked. Bob Sheppard has no intentions of returning to his longtime job as the public address announcer at Yankee Stadium, MLB.
The seven-time major championship winner also celebrated his 80th birthday on Sept. For more info see News Jerry Remy is working in the Boston Red Sox broadcast booth for the first time in more than three months. It was widely speculated that Scully would retire at the end of this season when his contract was up. Lee plans to be back for the start of the regular season which starts in late August.
Louis rams' radio broadcasts. Farr will be the in-game color analyst this season while Hanifan will be the pre-and post-game analyst. He is joined by Krystal Fernandez. Steve White and Brandon Guzio have taken over the midday spot. Detroit Tigers radio broadcaster Dan Dickerson is taking some time off to have surgery following a jogging accident and will be replaced by John Keating. Mary Carillo, and Max Kellerman.
Ken Stabler will not return as radio analyst on niversity of Alabama football broadcasts. Stabler had been on leave since being arrested on a D. Retired sportscaster Les Keiter died in Hawaii at age 89 after a long illness. Harry Kalas became the third person to ever have a public viewing in a baseball stadium. He was 82 years old. BAT helps former major league players who are in financial trouble.
The former NBA star was arrested Dec. Steve Bartelstein , the weekend news anchor, is expected to also do the sports on his newscasts.
Sutton is rejoining the Atlanta Braves radio broadcast team. For the time being, Baltimore Sun sports columnist Peter Schmuck will fill some of the talk hours.
Turner Sports is celebrating 25 years of covering the NBA. Scully was recently voted No. Santos will continue as the voice of the New England patriots. Joe Starkey has retired as the voice of the San Francisco 49ers and will be replaced by Ted Robinson.
Starkey will continue as the voice of the University of California's college football team. Barnett will continue his college football and basketball duties at ESPN. Tony Kubek has been awarded the Ford C. Tim Neverett will replace the recently retired Lanny Frattare in the Pittsburgh Pirates broadcasting booth. Neverett worked for FSN Rocky Mountain as a pre-and post-game studio host and part-time play-by-play announcer for Colorado Rockies telecasts.
John Gordon has signed a two-year contract extension to continue as radio play-by-play man for the Minnesota Twins. The Baltimore Orioles have announced that Gary Thorne will be returning as their TV play-by-play voice next season and Amber Theoharis will return as the in-game reporter. Lanny Frattare has retired as the voice of the Pittsburgh Pirates after a career that spanned over three decades. Ralph Strangis and Darryl Reaugh have signed long-term contract renewals to continue to broadcast Dallas Stars hockey through the season.
Dick Lynch , who starred at cornerback for the New York Giants during their glory years in the late s and early s and was a longtime radio analyst for the team, has died. Steve Stone will move over from the radio booth to be the color analyst on Chicago White Sox telecasts next season, replacing Darren Jackson.
Bob Wolff , one of the most honored and longest-running sportscasters in the nation, received the Curt Gowdy Media Award from the Naismith Basketball Hall of Fame during their annual induction ceremonies on September 5 in Springfield, Mass. Jason is replacing Pat Foley , who is returning to work Chicago Blackhawks games after two seasons away. CBS Television and the Southeastern Conference have agreed on a year contract extension to continue broadcasting football and basketball games.
Darren Goldwater is the new radio voice of The Citadel college football games. Peck replaces Howard Simon. Louis will not be renewing the contracts of their morning hosts, Joe DeNiro and Brian McKenna , but the station will allow them to remain indefinitely.
Skip Caray , a voice of the Atlanta Braves for 33 years and part of a family line of baseball broadcasters that included ASA Hall of Famer Harry Caray, died in his sleep at home on Sunday, the team said.
Bobby Murcer , a five-time All-Star outfielder who spent nearly four decades with the New York Yankees as a player, executive and announcer, has died. The Yankees said Murcer died Saturday, June 12, due to complications from brain cancer.
He was surrounded by family at Mercy Hospital in his hometown of Oklahoma City, the team said. Papa is also the radio voice of the New York Giants. Louis, has been fired in a cost-cutting move.
Barry Melrose , who has been a studio hockey analyst for ESPN for 12 years, is leaving the network to become the head coach of the Tampa Bay Lightning.
North and the station could not agree on new contract terms. Charlie Jones , the deep-voiced sportscaster whose career as a play-by-play announcer dated to the beginning of the American Football League in , has died.
Yet he may best be remembered for that grim day at the Munich Olympics when he broke the news with three simple words: The Bulls will honor Kerr for his longtime service with the team with a sculpture that will be on display at the United Center.
Paul, will leave the station when his contract is up in October. Louis beginning May 27 in early afternoons. Dimino is leaving the St. FSN West broadcaster Bill MacDonald is recovering from prostate cancer surgery and will be off the air for approximately six weeks. His legendary career in Boston included broadcasting games for all four professional sports teams and the Harvard-Yale football game. Reynolds also works for MLB.
Bryant Gumbel has left his broadcasting position at the NFL network. For full story see News Legendary University of Georgia football broadcaster Larry Munson had successful surgery on April 4th to remove blood clots on his brain. Munson is expected to make a full recovery and plans to be the primary UGA p-b-p announcer in Anyone wishing to send Larry best wishes can at: Box , Athens, GA.
Lobel joined the station in as a weekend sports anchor and took over the weekday position two year later. Darren Smith , the afternoon co-host at XX Sports radio in San Diego, has signed a multi-year contract extension to continue on the station. An emotional Dick Vitale , in his fourth time being nominated for enshrinement into the Naismith Memorial Basketball Hall of Fame, was one of seven selected Monday, April 7, to the class of Campbell was the radio analyst for the series previously.
When Brent Musberger broadcast the Cubs vs. After leaving TV, Mr. Callaghan worked for the Massachusetts state government in a variety of positions. ESPN has announced that their baseball analyst, Rick Sutcliffe , has been diagnosed with a treatable form of colon cancer and will miss several months of the upcoming baseball season while he undergoes surgery and chemotherapy. Scott Russell and Diana Swain will host the morning coverage and Ian Hanomansing will host late-night coverage.
Holley joined WEEI in For the first time since , there won't be a Buck in a St. Louis Cardinals broadcast booth this year. ASA Lifetime Member Joe Buck , who had been doing the play-by-play for a few Redbirds games on FSN Midwest in recent seasons, has decided not to return in order to enjoy himself at the ballpark in a nonworking capacity. Former All-Pro wide receiver Cris Carter will replace him. Best wishes to Bobby Murcer who will be undergoing a biopsy to see if he has had a recurrence of brain cancer.
Myron Cope spoke in a language and with a voice never before heard in a broadcast booth, yet a loving Pittsburgh understood him perfectly during an unprecedented 35 years as a Steelers announcer.
The screechy-voiced Cope, a writer by trade and an announcer by accident whose colorful catch phrases and twirling Terrible Towel became nationally known symbols of the Steelers, died Wednesday at age Niehaus, a fixture in the Seattle Mariners' booth since they entered the American League as an expansion franchise in , was named the winner of the Ford C.
Charlie Slowes has resigned to return to the Washington Nationals radio booth as lead announcer for He rejoins Dave Jageler who signed a new deal earlier in the off-season.
David Cone has been hired by the New York Yankees as a baseball analyst. Cone will work from games split between the studio and the booth. After undergoing throat surgery Dec. Wayne Hagin has been hired to be the No. Geffner shared the Boston Red Sox No. Jack Eagle was a noted actor and comedian who was most famous for portraying a monk, Brother Dominick, on a Xerox commercial which first aired during the Super Bowl in