Views Read Edit View history. A systematic review concluded no data exists to definitively link metformin to lactic acidosis. The usual synthesis of metformin, originally described in , involves the one-pot reaction of dimethylamine hydrochloride and 2-cyanoguanidine over heat. Furthermore, the lipid solubility of the nonionized species is slight as shown by its low logP value log 10 of the distribution coefficient of the nonionized form between octanol and water of Activation of AMPK was required for metformin's inhibitory effect on liver glucose production.
Again, if you don't mind the jitters and all that jazz, it may be worth your time to check out the LipoVida brand. Otherwise, Pure GCE gets my vote. Good product except the product isn't the best. I've tried a few different brands and this isn't the worst but it's not the best. Personally I would recommend another brand.